Biochemistry 118

Sophomore Seminar

Genomics & Medicine

Personal Genomics Lecture Slides

Personal Genomics and Genetic Testing

23andMe

Technical Papers and Standards
Guidelines on Vetting Genetic Associations
Estimating Genotype-Specific Incidence for One or Several Loci
Estimating Genotype-Specific Incidence in the Context of Ethnic Variation
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DNADirect

Charlie Rose Discusses Personal Genomics with George Church and Steve Pinker

Recent Literature Reviews

Other Literature References

• Clinical Assessment Incorporating a Personal Genome. Ashley, E. et al. (2010) Lancet 375, 1525-1535.

• Emerging genomic applications in coronary artery disease. Damani SB and Topal EJ, JACC Cardiovasc. Intervention (2011). 4:473-482.

• Clinical applicability of sequence variations in genes related to drug metabolism. Stojiljkovic et al. (2011) Curr Drug Metab. 1;12(5):445-54.

• Clinical pharmacogenetics and potential application in personalized medicine. Zhou et al., (2008) Curr Drug Metab. 9(8):738-84.

• Genes, mutations, and human inherited disease at the dawn of the age of personalized genomics. Cooper et al (2010) Hum Mutat. 31(6):631-55.

• Excess of rare variants in genes identified by genome-wide association study of hypertriglyceridemia. Johansen et al. (2010) Nature Genetics 42: 684-688.

• Finding the missing heritability of complex diseases. Manolio, T.A. et. al., (2009) Nature 461, 747-753.

• Rare Variants Create Synthetic Genome-Wide Associations. Dickson, S. P.. et al. (2010) PLOS Biology 8, 1-12.

• •Web-based, participant-driven studies yield novel genetic associations for common traits. Eriksson et al. (2010) PLoS Genetics 6, e1000993.

Medical Grand Rounds

Euan Ashley - So What Is Precision Medicine Anyway?